1 (1) Saleh Sassoon (1750-1830)
1.1 (2) David Sassoon (David Ben Sassoon) (1792–1864), married: 1) Hannah Joseph, daughter of Abdullah Joseph 2) Flora (Farha) Hayim, daughter of Freddy Faraj Hayim (Furraj Hyeem) and Rifka Elkebir Gubbay (daughter of Heskel Elkebir Gubbay (1740-1816) and Ades Elkebir Gubbay, sister of Shoua Heskel Elkebir (see below)), in 1828
1.1.1 (3) Sir Albert Abdullah David Sassoon (1818–1896), 1st Baronet of Kensington Gore, married Hannah Moses, daughter of Meyer Moses.
1.1.1.1 (4) Aziza Abraham Sassoon, married Ezekiel Abraham (Heskel Shoua Heskel Elkebir) (1824-1896) (son of Shoua Heskel Elkebir (see above) and Mazaltov (Muzli Toba) Somekh)
1.1.1.1.1 (5) Flora (Farha) Abraham (1856-1936), married Solomon David Sassoon (1841–1894) (see below)
1.1.1.2 (4) Rachel Gubbay
1.1.1.3 (4) Joseph Albert Sassoon
1.1.1.4 (4) Mozelle Ezra
1.1.1.5 (4) Sir Edward Sassoon (1856–1912), 2nd Baronet of Kensington Gore, married Aline Caroline de Rothschild, daughter of Gustave de Rothschild and Cécile Anspach, in 1887.
1.1.1.5.1 (5) Sir Philip Sassoon (1888–1939), 3rd Baronet of Kensington Gore
1.1.1.5.2 (5) Sybil Cholmondeley, Marchioness of Cholmondeley (1894-1989), she married George Cholmondeley, 5th Marquess of Cholmondeley
1.1.2 (3) Elias David Sassoon (1820–1880), businessman
1.1.2.1 (4) Jacob Elias Sassoon (1844–1916), first Baronet
1.1.2.1.1 (5) Mary Sheung Mei Zimmern
1.1.2.2 (4) Hannah David
1.1.2.3 (4) Sir Edward Elias Sassoon (1853–1924), 2nd Baronet of Bombay
1.1.2.3.1 (5) Lydia Weisweiller
1.1.2.3.2 (5) Hector Sassoon
1.1.2.3.3 (5) Sir Victor Sassoon (Ellice) (1881–1961), 3rd Baronet
1.1.2.3.4 (5) Isabelle Rosalind Humphreys-Owen
1.1.2.4 (4) Charles Sassoon
1.1.2.5 (4) Joseph Sassoon
1.1.2.6 (4) Meyer Sassoon (1855-1924)
1.1.2.7 (4) Rachel Solomon
1.1.2.8 (4) Sarah Sassoon
1.1.2.9 (4) Aziza Abraham
1.1.2.10 (4) David Sasoon
1.1.2.11 (4) Cesar Sassoon
1.1.3 (3) Amam Moses
1.1.4 (3) Mazaltob Sassoon
1.1.5 (3) Sassoon David Sassoon (1832–1867), British Indian merchant, married Flora (Fahra) Reuben (1837-1919)
1.1.5.1 (4) Joseph Sassoon Sassoon (1855-1918), married Baroness Louise de Gunzburg (1862-1921)
1.1.5.1.1 (5) Captain Sassoon Joseph Sassoon (1885-1922), married Dulcie Franklin, daughter of Frederic Samuel Franklin and Lucy Amy Magnus, on 12 March 1919.
1.1.5.1.1.1 (6) Penelope Louise Sassoon (b. 1920), married 1) F/Lt. Michael Ingoldsby Massy, son of Major William Ingoldsby Justice Massy and Adam Mary Frances Simpson, on 18 May 1944 2) Serge Horace de Genzburg, son of Baron Vladimir de Genzburg, on 8 September 1948.
1.1.5.1.2 (5) Major Arthur Meyer Sassoon (b. 1889), married Doris Meyer.
1.1.5.1.2.1 (6) Hugh Meyer Sassoon (b. 1929), married Marion Julia Schiff.
1.1.5.1.2.1.1 (7) James Sassoon (born 1955), British businessman and government minister, married Sarah Caroline Ray Barnes, daughter of Sir Ernest John Ward Barnes, in 1981.
1.1.5.1.3 (5) Major Frederick Sassoon (b. 1892), married Margaret Lucy Franklin, daughter of Frederic Samuel Franklin and Lucy Amy Magnus, on 27 March 1919.
1.1.5.1.3.1 (6) Dr. Humphrey Frederick Sassoon (b. 1920), married Mary Patricia Boord, daughter of Captain Sydney John Savage Boord and Mary Ethel Margaret Copeman, on 8 June 1956.
1.1.5.1.3.1.1 (7) Timothy John Frederick Sassoon (b. 1957)
1.1.5.1.3.1.2 (7) Mark Richard Humphrey Sassoon (b. 1959)
1.1.5.1.3.1.3 (7) Clare Penelope Mary Sassoon (b. 1961)
1.1.5.2 (4) Rachel Beer
1.1.5.3 (4) Alfred Ezra Sassoon (1861–1895), married Theresa Georgina Thornycroft, daughter of Thomas Thornycroft and Mary Francis, in 1882.
1.1.5.3.1 (5) Siegfried Sassoon (1886–1967), poet, especially on the subject of World War I, married Hester Gatty in 1933.
1.1.5.3.1.1 (6) George Sassoon (1936–2006), English scientist, electronic engineer, linguist, translator and author, married: 1) Stephanie Munro in 1955 2) Marguerite Dicks in 1961 3) Susan Christian-Howard in 1975 4) Alison Pulvertaft.
1.1.5.3.1.1.1 (7) Kendall Sassoon
1.1.5.3.1.1.2 (7) Isobel Hannah Sassoon (1976-1996)
1.1.5.3.1.1.3 (7) Thomas Thornycroft Sassoon (1978-1996)
1.1.5.3.2 (5) Michael Thornycroft Sassoon (1884–1969)
1.1.5.3.2.1 (6) Alfred Lionel "Léo" Sassoon
1.1.5.3.2.2 (6) Norman Basil Arundel "Patrick" Sassoon
1.1.5.3.2.3 (6) Hamo Sassoon (1920-2004), married Flavia Sybil Adeva Kingscote (1911-1946), daughter of Lt.-Col. Randolph Albert Fitzhardinge Kingscote and Elizabeth Butler, on 12 January 1946.
1.1.5.3.3 (5) 2nd Lt. Hamo Watts Sassoon (1887–1915)
1.1.5.4 (4) Frederick Meyer Sassoon
1.1.6 (3) Reuben David Sassoon (1835–1905), married Catherine Sassoon (1838–1906).
1.1.6.1 (4) Mozelle Sassoon
1.1.6.2 (4) Louise Judith Sassoon (1874-1964), married Sir Charles Cavendish Boyle, son of Cavendish Spencer Boyle and Rose Susan Alexander, on 9 July 1914.
1.1.7 (3) Arthur Sassoon (1840-1912), married (Eugenie) Louise (Perugia) Sassoon (1854-1943), daughter of Signor Achille Perugia of Trieste, Italy, whose sister Marie Perugia (1862–1937) was married to Leopold de Rothschild (1845-1917)
1.1.8 (3) Solomon David Sassoon (1841–1894), married Flora Sassoon (1859-1936), daughter of Ezekiel Abraham Gubbay (1824–1896) and Aziza Sassoon (1839–1897)
1.1.8.1 (4) Lady Rachel Ezra (1877–1952), married David Ezra
1.1.8.2 (4) Mozelle Sassoon (1884–1921)
1.1.8.3 (4) David Suleiman Sassoon (1880-1942)
1.1.8.3.1 (5) Flora Farcha Farha Feuchtwanger
1.1.8.3.2 (5) Rabbi Solomon David Sassoon (1915–1985), Talmudic scholar and writer
1.1.8.3.2.1 (6) Rabbi Isaac S.D. Sassoon, Sephardic Orthodox rabbi
1.1.9 (3) Aaron Sassoon (1841-1907)
1.1.10 (3) Catherine "Kate" Ezekiel Sassoon (1844-1917)
1.1.11 (3) Rebecca Sassoon Shellim (1847-1918)
1.1.12 (3) Simha Sassoon (1850-1857)
1.1.13 (3) Frederick David Sassoon (1853-1917), married the daughter of Edward L. Raphael.
1.1.13.1 (4) Ronald Edward David Sassoon
1.1.14 (3) Mozelle Sassoon Hayeem (1855-1952)
1.1.15 (3) David Sassoon